Alzheimer’s Disease is one of the most common causes of dementia. According to who it accounts for 60-70% of all cases of dementia.
briefly Explain that dementia is a syndrome in which the gradual destruction of memory and thinking, behavior change, and the loss of the ability to perform normal everyday tasks.
there are about 50 million people suffer from Alzheimer’s disease. And this is a big social problem, because the disease depressing effect not only on sick but also on family members who care for such patients.
Recall that scientists have long established that the disease is associated with accumulation in the brain of the patient of beta-amyloid plaques and the so-called neurofibrillary tangles, consisting of hyperphosphorylation of the Tau protein.
Their deposition leads to disruption of normal structure of the tissues of the brain and decrease cognitive abilities.
And if the reasons for this heavy progressive state professionals in General clear, his treatment fared much worse.
Modern approaches to therapy of Alzheimer’s disease is mainly aimed at reduction of pathological deposits of amyloid or Tau proteins. However, clinical trials of the various tools proposed in recent years, still has not shown its efficiency in containing the disease in humans.
Recently the Australian-American research group, which, incidentally, included many former Russian scientists proposed a different approach to the prevention and treatment of Alzheimer’s disease.
In the scientific work of the experts report that lead to neurodegeneration are not just deposits of the two proteins, but their joint interaction.
According to experts, working under the guidance of Professor Nikolai Petrovsky (Nikolai Petrovsky) from Flinders University in Australia, a simultaneous “attack” on Tau and amyloid proteins, it helps to contain and even reverse the progression of the disease.
in orders to prove their theory, the scientists created a “cure for dementia”. The drug, called Advax, is a combination of two compounds acting together both pathological protein.
At the stage of preclinical animal testing, the drug was injected laboratory mice intramuscularly. Explain that used rodents was a kind of animal model of the disease in their brain after genetic modification began to produce “human” proteins associated with Alzheimer’s disease, say the authors.
during the study it was found that the combination of the two substances causes the production of large quantities of specific antibodies.
moreover, these antibodies are actively “recognize” and attack the amyloid plaques and neurofibrillary tangles in the brain of experimental animals. That is the principle of operation of Advax is fully consistent with the mechanism of action of vaccines.
After four injection 20 micrograms of the drug amount of amyloid and Tau deposits in the brain of laboratory mice significantly decreased.
“the Vaccine is effective to prevent memory impairments in animals with developing protein deposits. In addition, we also showed the effectiveness of the drug for control of existing pathological plaques [in the brain]”, – said Mykola Petrovsky in an interview with the Australian ABC News.
the Authors believe that the use of combination vaccines Advax will be the key to treatment of Alzheimer’s disease in humans.
Experts plan to conduct clinical trials of its development on the people in the next two years, reports the New Atlas.
If the studies are successful, the “cure for dementia” promises to be one of the medical breakthroughs of the next decade, say the authors.
for More detailed results of new scientific research are freely accessible in the medical journal Alzheimer’s Research & Therapy.
earlier, the authors “Conduct.Science” (nauka.vesti.ru) talked about why Alzheimer’s disease “prefers” women and some ways to prevent development of this serious problem, and about the conflicting drug from this devastating disease, which is already approved for use in China.
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