To test a vaccine against coronavirus COVID-19 at the Institute of gene biology of RAS received more than 20 mice with the human genome, and every day scientists are finding even three or four needs of the individual. Parallel to the process of improvement of transgenic models, told in the film Naila Asker-zade “Threat virus. The vaccine” on TV channel “Russia 1” the head of the center for collective use “Genome editing” of the Institute of gene biology of RAS Alexey Deykin.
the Fact that ordinary rodents react to the new coronavirus differently than a man, it became clear in late February. The virus enters the human cells use the protein АСЕ2, which is its receptor, and the entry point into the cell.
Here’s the difference between mouse and man significant: cells from mice with this virus gets too bad, and they can infect only very high dose. And carry coronavirus infection in normal mice is extremely easy, with no symptoms.
According to Dakin, the scientists slaughtered in the nucleus system of mice with two human genes. The next step is humanizing: they do not just transgenes, when the genome of mice, inserted human genes, and the replacement of murine gene to the human.
“now we’ve got these humanized mice of the first generation. They are unique in Russia received for the first time in the world there is not” — said the scientist.
